The recommendations in this guidance represent the view of NICE, arrived at after carefulconsideration of the evidence available. When exercising their judgement, healthprofessionals are expected to take this guidance fully into account, alongside theindividual needs, preferences and values of their patients. The application of therecommendations in this guidance is at the discretion of health professionals and theirindividual patients and do not override the responsibility of healthcare professionals tomake decisions appropriate to the circumstances of the individual patient, in consultationwith the patient and/or their carer or guardian.